Aksenov, Alexander V.; Aksenov, Dmitrii A.; Arutiunov, Nikolai A.; Aksenov, Nicolai A.; Aleksandrova, Elena V.; Zhao, Zhenze; Du, Liqin; Kornienko, Alexander; Rubin, Michael published the artcile< Synthesis of Spiro[indole-3,5'-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles>, Application In Synthesis of 5153-70-8, the main research area is spiroindoleisoxazole preparation anticancer formal spirocyclization nitroalkene indole.
An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4’H-spiro[indole-3,5′-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic mols. exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells.
Journal of Organic Chemistry published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Application In Synthesis of 5153-70-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics