Asgari, Mohammad Sadegh; Bahadorikhalili, Saeed; Ghaempanah, Aram; Rashidi Ranjbar, Parviz; Rahimi, Rahmatollah; Abbasi, Alireza; Larijani, Bagher; Mahdavi, Mohammad published the artcile< Copper-catalyzed one-pot synthesis of amide linked 1,2,3-triazoles bearing aryloxy skeletons>, Application In Synthesis of 611-19-8, the main research area is aryloxy amide linked triazole preparation copper catalyst; bromopropynyl benzamide benzyl halide one pot click reaction.
In this paper, novel amide linked 1,2,3-triazoles containing aryloxy derivatives were synthesized via copper-catalyzed one-pot sequential hydroxylation-O-alkylation/click reaction of 2-bromo-N-prop-2-ynyl-benzamides. The products were synthesized in an efficient way in high isolated yields. The synthetic method involves the use of 2-bromo-N-prop-2-ynyl-benzamide and various benzyl halides over a one-pot copper-catalyzed hydroxylation-O-alkylation/click reaction. In-situ prepared phenol moiety in H2O/DMF as a solventco-solvent system prompted to perform a reaction between benzyl halide and phenols. The step economic feature of the method leads to the synthesis of the products in high isolated yields.
Tetrahedron Letters published new progress about Benzyl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Application In Synthesis of 611-19-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics