Byun, Youngjoo; Vogel, Susan R.; Phipps, Andrew J.; Carnrot, Cecilia; Eriksson, Staffan; Tiwari, Rohit; Tjarks, Werner published the artcile< Synthesis and Biological Evaluation of Inhibitors of Thymidine Monophosphate Kinase from Bacillus anthracis>, Application of C7H7ClO4S2, the main research area is thymidine phosphate analog preparation inhibitor Bacillus thymidine monophosphate kinase.
Nineteen lipophilic thymidine phosphate-mimicking compounds were designed and synthesized as potential inhibitors of thymidine monophosphate kinase of Bacillus anthracis, a Gram-pos. bacterium that causes anthrax. These thymidine analogs were substituted at the 5′-position with sulfonamide-, amide-, (thio)urea-, or triazole groups, which served as lipophilic surrogates for phosphate. Three of the tested compounds produced inhibition of B. anthracis growth and/or thymidine monophosphate activity. Addnl. studies will be necessary to elucidate the potential of this type of B. anthracis thymidine monophosphate inhibitors as novel antibiotics in the treatment of anthrax.
Nucleosides, Nucleotides & Nucleic Acids published new progress about Anthrax (disease). 5335-40-0 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO4S2, Application of C7H7ClO4S2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics