Cai, Zhengyan; Wen, Yingling; Zhang, Xuli; Liu, Zhenren; Hao, Qun published the artcile< Preparation and structural confirmation of the related substances of rivaroxaban>, Computed Properties of 31166-29-7, the main research area is rivaroxaban related substance synthesis.
According to the structural characteristics of rivaroxaban and its synthetic process, eight related substances: 5-chloro-N-[[2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide (A), N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1, 3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide (B), 4,5-dichloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl]methyl] thiophene-2-carboxamide (C), (S)-2-[[[2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl] methyl] carbamoyl] benzoic acid (D), N1, N2-bis-[[(S)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1, 3-oxazolidin-5-yl] methyl] phthalamide (E), 5-chloro-N-methylthiophene-2-carboxamide (F), 5-chloro-N,N-dimethylthiophene-2-carboxamide (G) and 1,3-bis-[[(S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl] methyl] urea (H), were synthesized and confirmed by 1H NMR and MS. These substances were taken as the references for the quality control of rivaroxaban.
Zhongguo Yiyao Gongye Zazhi published new progress about 31166-29-7. 31166-29-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C5H2Cl2O2S, Computed Properties of 31166-29-7.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics