Chandrasekhar, K. B.; Narisetty, Rajasekhar published the artcile< Synthesis, characterization and antibacterial evaluation of some novel hydrazone derivatives of 3-chloro-4-hydroxy-benzoic acid>, SDS of cas: 3964-57-6, the main research area is hydrazone chloro hydroxybenzoic acid preparation antibacterial.
The synthesis and antibacterial activity of a series of fifteen new hydrazide-hydrazone derivatives I (R = 4-MeO, 4-F, 4-CF3, 2-CF3, 2,4-F2, etc.) via coupling of methyl-3-chloro-4-hydroxybenzoate and 3-chlorobenzyl chloride is reported. The newly synthesized fifteen hydrazone derivatives I have been screened against four chosen bacterial strains viz., E. coli, P. aeruginosa, S. aureus and S. pyogenes with ampicillin as the standard drug. It is observed that compounds I (R = 2,4-F2, 3,4-F2, 2-Me-4-F)exhibit excellent antibacterial activity (zone of inhibition 21-24 mm), while compounds having 4-CF3, 4-OCF3 and 2-CF3 substituents display equipotent antibacterial activity (zone of inhibition 19-22 mm).
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Antibacterial agents. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, SDS of cas: 3964-57-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics