Chen, Jiajia; Xia, Yuanzhi; Lee, Sunwoo published the artcile< Coupling of amides with ketones via C-N/C-H bond cleavage: a mild synthesis of 1,3-diketones>, Application In Synthesis of 17082-09-6, the main research area is diketone preparation; amides ketone coupling.
A variety of aryl and alkyl-substituted tertiary amides reacted with ketones in the presence of LiHMDS and a variety of primary and secondary amides in one pot to gave the corresponding 1,3-diketone products R1C(O)CH(R3)C(O)R2 [R1 = octyl, Ph, 4-MeC6H4, etc.; R2 = t-Bu, Ph, 2-BrC6H4, etc.; R3 = H, Me, n-Pr, hexyl] in good to excellent yields via C-N cleavage of amides and deprotonation of ketones. The reaction was conducted at room temperature under transition-metal-free conditions. N-Tosyl-, N-triflyl-, N-mesyl-, and N-Boc-substituted tertiary amides including N-benzoyl saccharin and N-benzoyl succinimide showed good activity in the reaction. The broad scope, good functional group tolerance of substrates and gram-scale synthesis showed the great importance and potential of this protocol in organic synthesis and industrial manufacture
Organic Chemistry Frontiers published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics