Duan, Y. T.; Parmar, T. H.; Sangani, C. B.; Shah, A. S.; Ameta, R. K. published the artcile< 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-Oxide Hexafluorophosphate (HATU)/Hydroxybenzotriazole (HOBT)-based One-Pot Cyclization of N-Substituted 2-Arylbenzimidazole Derivatives>, SDS of cas: 85740-98-3, the main research area is benzoic acid methyl phenylenediamine HATU HOBT cyclocondensation green chem; phenyl methylbenzimidazole preparation.
A simple one-pot synthesis of N-methyl-phenylbenzimidazoles was developed from substituted benzoic acids and N-methyl-o-phenylenediamine in the presence of 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate/hydroxybenzotriazole (HATU/HOBT) and N,N-diisopropylethylamine in DMF at 100° C, featuring good to excellent yields and easy workup. The protocol was scaled to gram quantities, and no chromatog. purification was required.
Russian Journal of Organic Chemistry published new progress about Benzimidazoles Role: SPN (Synthetic Preparation), PREP (Preparation). 85740-98-3 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, SDS of cas: 85740-98-3.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics