Jui, Nathan T.; Buchwald, Stephen L. published the artcile< Cascade Palladium Catalysis: A Predictable and Selectable Regiocontrolled Synthesis of N-Arylbenzimidazoles>, Electric Literature of 35852-58-5, the main research area is regioselective preparation arylbenzimidazole; cascade intermol amination amidation chloroaryl sulfonate halide; chemoselectivity; cross-coupling; heterocycles; palladium; synthetic methods.
Regioselective N-arylbenzimidazole was prepared via cascade intermol. amination and amidation reactions of 2-chloroaryl sulfonates (or halides). A single catalyst, based on iBuBrettPhos, is able to selectively perform both catalytic elements of this process for a broad range of arylamine (or heteroarylamine), amide, and bifunctional electrophile substrates to afford the corresponding benzimidazole products with complete regioselectivity. Moreover, it was demonstrated that different 2-chloroaryl sulfonates (triflate vs. mesylate), which are derived from the same chlorophenols, can be reacted under very similar reaction conditions to exclusively afford the opposite regioisomeric heterocycles.
Angewandte Chemie, International Edition published new progress about Amidation. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Electric Literature of 35852-58-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics