Kajimoto, Chihiro; Yamada, Shigeyuki; Konno, Tsutomu published the artcile< Novel multi-functionalized fluorine-containing organometallics: Preparation and applications of tetrafluoroethylenated zinc reagent>, Application In Synthesis of 17082-09-6, the main research area is bromotetrafluorobutene zinc bromide preparation acid chloride copper coupling reaction; bromo tetrafluoropentenone preparation; iodoarene bromotetrafluorobutene zinc bromide cross coupling reaction; tetrafuoro bromo arylbutene preparation.
On treating 2,4-dibromo-3,3,4,4-tetrafluorobut-1-ene, readily prepared from com. available 4-bromo-3,3,4,4-tetrafluorobut-1-ene, with 2.0 equivalent of zinc-silver alloy at 40 C in CH3CN, zinc insertion at the terminal C(sp3)-Br site proceeded selectively, giving the corresponding (3-bromo-1,1,2,2-tetrafluorobut-3-en-1-yl)zinc bromide in high yield. This organozinc reagent was found to be thermally stable and easily handled. It was found that this organozinc reagent was participated in the cross-coupling reaction with various acyl chlorides or iodoarenes to give the corresponding CF2CF2-containing organic mols. in good yields. It was also revealed that Suzuki-Miyaura cross-coupling reactions at the C(sp2)-Br site of these CF2CF2-substituted products also proceeded in good to excellent yields.
Journal of Fluorine Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics