Khadse, Saurabh C.; Talele, Gokul S.; Agrawal, Surendra S. published the artcile< Aminocarbonyl Arylvinylbenzamides as Gastric Sparing Anti-inflammatory Agents>, HPLC of Formula: 29027-20-1, the main research area is aminocarbonyl arylvinylbenzamide preparation antiinflammatory gastrotoxicity gastrointestinal ulcer hypermotility.
Some (E/Z)-aminocarbonyl arylvinylbenzamides (B1-B15) were synthesized, evaluated for anti-inflammatory activity and ulcerogenic tendency, and their effect on gastro-intestinal motility in the rats was studied. These benzamides comprising of aliphatic unsaturated region situated between two amide linkages were synthesized by nucleophilic ring opening of appropriate az-lactones (AZ1-AZ4) by suitable amines. The characterization of newly synthesized benzamides was performed by IR, 1H- and 13C-NMR, mass and elemental anal. Amongst the tested compounds, benzamide B1, B2, B4, B5, and B13 were able to produce comparable or superior anti-inflammatory activity at 10 and 20 mg/kg p.o. dose with respect to standard diclofenac in carrageenan induced rat paw edema model with lessened propensity to cause gastro-intestinal hypermotility and were found to have nil tendencies to generate gastric ulcers.
Archiv der Pharmazie (Weinheim, Germany) published new progress about Anti-inflammatory agents. 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, HPLC of Formula: 29027-20-1.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics