Khairnar, Pankaj V.; Lung, Tsai-Hui; Lin, Yi-Jung; Wu, Chi-Yi; Koppolu, Srinivasa Rao; Edukondalu, Athukuri; Karanam, Praneeth; Lin, Wenwei published the artcile< An Intramolecular Wittig Approach toward Heteroarenes: Synthesis of Pyrazoles, Isoxazoles, and Chromenone-oximes>, Synthetic Route of 17082-09-6, the main research area is diversity oriented synthesis pyrazole isoxazole chromenone oxime; intramol Wittig reaction alpha halohydrazone ketoxime.
α-Halohydrazones/ketoximes are transformed into trisubstituted pyrazoles/disubstituted isoxazoles by treatment with phosphine, acyl chloride, and a base. Mechanistic investigations revealed the in situ formation of azo/nitroso olefin intermediates which underwent a tandem phospha-Michael/N- or O-acylation/intramol. Wittig reaction to afford the heteroarenes in moderate to good yields. Further, proper functionalization of α-haloketoximes and a change of conditions allowed the chemoselective synthesis of chromenone-oximes as well as rearranged isoxazoles, thereby realizing a diversity-oriented synthesis.
Organic Letters published new progress about Benzopyrans Role: SPN (Synthetic Preparation), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Synthetic Route of 17082-09-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics