Khairnar, Pankaj V.; Su, Yin-Hsiang; Chen, Yung-Chang; Edukondalu, Athukuri; Chen, Yi-Ru; Lin, Wenwei published the artcile< Organophosphane-Catalyzed Direct β-Acylation of 4-Arylidene Pyrazolones and 5-Arylidene Thiazolones with Acyl Chlorides>, Quality Control of 17082-09-6, the main research area is oxoarylidene pyrazolone preparation diastereoselective crystal structure mol; arylidene pyrazolone acyl chloride acylation organophosphane catalyst; oxo arylidene thiazolone preparation diastereoselective crystal structure mol; thiazolone arylidene acyl chloride acylation organophosphane catalyst.
An efficient method for the direct β-acylation of arylidene pyrazolones and thiazolones with acyl chlorides in the presence of a base catalyzed by organophosphanes was reported. A variety of oxoarylidene pyrazolones I [R1 = Me, i-Pr, Ph, etc.; R2 = Ph, 4-MeOC6H4, 4-FC6H4, etc.; R3 = Ph, 4-ClC6H4, 2-thienyl, etc.; R4 = Me, Ph, 2-thienyl, etc.] and oxoarylidene thiazolones II [R5 = Ph, 4-ClC6H4, 2-MeC6H4, etc.] were prepared under metal-free and mild conditions via a tandem phospha-Michael addition/O-acylation/intramol. cyclization/rearrangement sequence. Mechanistic investigations revealed that the reaction was highly stereospecific to provide exclusively cis-isomers and the methodol. could also be scaled up with similar efficacy.
Organic Letters published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Quality Control of 17082-09-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics