Kong, Xianqiang; Zhang, Huizi; Xiao, Yunqing; Cao, Changsheng; Shi, Yanhui; Pang, Guangsheng published the artcile< Effective, transition metal free and selective C-F activation under mild conditions>, HPLC of Formula: 1435-43-4, the main research area is aryl fluoride aniline amination; fluorophenylaniline preparation regioselective.
A simple and effective aromatic nucleophilic monosubstitution reaction for the synthesis of aromatic amines via selective C-F bond cleavage of various fluoroarenes (mono-, di-, tri-, tetra-, penta- and perfluorobenzene) with primary and secondary aromatic amines under transition metal free conditions was demonstrated. The reaction conditions were investigated thoroughly for a wide range of fluoroarene substrates bearing different numbers of fluorine atoms, and the results showed that the solvent and reaction temperature were very crucial for the successful substitution reactions. The established methods enabled the formation of nonfluorinated and partially fluorinated aromatic amines in good to excellent yields. Several functional groups were tolerated under the optimized conditions.
RSC Advances published new progress about Amination, regioselective. 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, HPLC of Formula: 1435-43-4.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics