Lemoine, Remy C.’s team published research in Bioorganic & Medicinal Chemistry Letters in 2010 | CAS: 54453-94-0

Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.SDS of cas: 54453-94-0

Lemoine, Remy C.; Petersen, Ann C.; Setti, Lina; Wanner, Jutta; Jekle, Andreas; Heilek, Gabrielle; deRosier, Andre; Ji, Changhua; Berry, Pamela; Rotstein, David published an article on January 15 ,2010. The article was titled 《Evaluation of secondary amide replacements in a series of CCR5 antagonists as a means to increase intrinsic membrane permeability. Part 1: Optimization of gem-disubstituted azacycles》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.SDS of cas: 54453-94-0 The information in the text is summarized as follows:

Replacement of a secondary amide with an N-acyl or N-sulfonyl gem-disubstituted azacyle in a series of CCR5 antagonists led to the identification of compounds with excellent in vitro HIV antiviral activity and increased intrinsic membrane permeability. The experimental process involved the reaction of Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0SDS of cas: 54453-94-0)

Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.SDS of cas: 54453-94-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics