Li, Liang; Yang, Dongfeng; Zhao, Zhongrui; Song, Yongkang; Zhao, Lei; Liu, Rui; Liu, Guohua published the artcile< Boron tetrafluoride anion bonding dual active species within a large-pore mesoporous silica for two-step successive organic transformaion to prepare optically pure amino alcohols>, Category: chlorides-buliding-blocks, the main research area is boron tetrafluoride mesoporous silica amino alc organic transformaion preparation; anion bonding; asymmetric catalysis; heterogeneous catalyst; silica; tandem reaction.
Development of a simple and easy handing process for preparation of multifunctional heterogenous catalysts and exploration of their applications in sequential organic transformation are of great significance in heterogeneous asym. catalysis. Herein, through the utilization of a BF4- anion-bonding strategy, we anchor conveniently both organic bases and chiral ruthenium complex into the nanopores of Me-FDU-12, fabricating a Lewis base/Ru bifunctional heterogeneous catalyst. As we envisaged, cyclic amine as a Lewis base promotes an intermol. aza-Michael addition between enones and arylamines, affording γ-secondary amino ketones featuring with aryl motif, whereas ruthenium/diamine species as catalytic promoter boosts an asym. transfer hydrogenation of γ-secondary amino ketones to γ-secondary amino alcs. As expected, both enhance synergistically the aza-Michael addition/asym. transfer hydrogenation one-pot enantioselective organic transformation, producing chiral γ-secondary amino alcs. with up to 98% enantioselectivity. Unique features, such as operationally simple one-step synthesis of heterogeneous catalyst, homo-like catalytic environment as well as green sustainable process make this heterogeneous catalyst an attracting in a practical preparation of optically pure pharmaceutical intermediates of antidepressants.
Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Aza-Michael reaction catalysts. 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Category: chlorides-buliding-blocks.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics