The author of 《Design, synthesis, and antifungal activity of novel 1,2,4-triazolo[4,3-c] trifluoromethylpyrimidine derivatives bearing the thioether moiety》 were Liu, Chunyi; Fei, Qiang; Pan, Nianjuan; Wu, Wenneng. And the article was published in Frontiers in Chemistry (Lausanne, Switzerland) in 2022. Recommanded Product: 3-Chlorobenzylchloride The author mentioned the following in the article:
Crop disease caused by fungi seriously affected food security and economic development. Inspired by the utilization of fungicide containing 1,2,4-triazole and trifluoromethylpyrimidine, a novel series of 1,2,4-triazolo[4,3-c]trifluoromethylpyrimidine derivatives I (R = CO2C2H5, 2-MeC6H4, 2-FC6H4, etc.) bearing the thioether moiety were synthesized. Meanwhile, the antifungal activities of the title compounds were evaluated and most compounds exhibited obvious antifungal activities against cucumber Botrytis cinerea, strawberry Botrytis cinerea, tobacco Botrytis cinerea, blueberry Botrytis cinerea, Phytophthora infestans, and Pyricularia oryzae Cav. Among the compounds, 5-methyl-7-(trifuoromethyl)-[1,2,4]triazolo[4,3-c]pyrimidine-3-thiol and I (R = 4-BrC6H4, 4-Br-2-FC6H3 and 2,6-diClC6H3) showed significant antifungal activities against three of the four Botrytis cinerea, which indicated the potential to become the leading structures or candidates for resistance to Botrytis cinerea. In the experiment, the researchers used 3-Chlorobenzylchloride(cas: 620-20-2Recommanded Product: 3-Chlorobenzylchloride)
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Recommanded Product: 3-Chlorobenzylchloride
Referemce:
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