Long, Zhou-Qing; Yang, Lin-Li; Zhang, Jun-Rong; Liu, Shi-Tao; Jiao Xie; Wang, Pei-Yi; Zhu, Jian-Jun; Shao, Wu-Bin; Liu, Li-Wei; Yang, Song published their research in Journal of Agricultural and Food Chemistry in 2021. The article was titled 《Fabrication of Versatile Pyrazole Hydrazide Derivatives Bearing a 1,3,4-Oxadiazole Core as Multipurpose Agricultural Chemicals against Plant Fungal, Oomycete and Bacterial Diseases》.HPLC of Formula: 5781-53-3 The article contains the following contents:
An array of versatile pyrazole hydrazide derivatives bearing a 1,3,4-oxadiazole core I [R = Ph, 3-FC6H4, 4-MeOC6H4, etc.; R1 = 1H-pyrrol-2-yl, 1H-indol-2-yl, 3-(difluoromethyl)-1-methyl-pyrazol-4-yl, etc.] were initially synthesized and biol. evaluated the antifungal, antioomycetes and antibacterial activities. In addition, the pyrazole ring was replaced by the correlative pyrrole, thiazole and indole scaffolds to extend the mol. diversity. The results showed that most of these hybrid compounds were empowered with multifunctional bioactivities. For the antifungal activity, the minimal EC50 values could afford against the corresponding fungi Gibberella zeae, Fusarium oxysporum, Botryosphaeria dothidea and Rhizoctonia solani. In vivo pot experiments against corn scab (caused by G. z.) revealed that the compound I [R = 2-FC6H4; R1 = 3-(difluoromethyl)-1-methyl-pyrazol-4-yl] was effective with protective and curative activities of 90.2 and 86.3% at 200μg/mL, which was comparable to those of fungicides boscalid and fluopyram. Further mol. docking study and enzymic activity anal. indicated that target compounds were promising succinate dehydrogenase inhibitors. Addnl., compounds I [R = Ph, 4-FC6H4; R1 = 3-(difluoromethyl)-1-methyl-pyrazol-4-yl, 1-methyl-3-(trifluoromethyl)pyrazol-4-yl] yielded superior anti-oomycete and antibacterial activities toward Phytophora infestins and Xanthomonas oryzae pv. oryzae with EC50 values of 2.92 and 8.43μg/mL, resp. In vivo trials against rice bacterial blight provided the control efficiency within 51.2-55.3% at 200μg/mL, which were better than that of bismerthiazol. Given their multipurpose characteristics, these structures should be pos. explored as agricultural chems. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3HPLC of Formula: 5781-53-3)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.HPLC of Formula: 5781-53-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics