Luo, Yong; Ding, Hao; Zhen, Jing-Song; Du, Xian; Xu, Xiao-Hong; Yuan, Han; Li, Yi-Hui; Qi, Wan-Ying; Liu, Bing-Zhe; Lu, Shi-Man; Xue, Can; Ding, Qiuping published the artcile< Catalyst-free arylation of sulfonamides via visible light-mediated deamination>, Synthetic Route of 5335-40-0, the main research area is diaryl sulfone preparation photochem; sulfonamide aryl boronic acid arylation deamination visible light.
A novel arylation of sulfonamides RSO2N(R1)C(O)R2 (R = 4-methylphenyl, naphthalen-2-yl, 2,3-dihydro-1-benzofuran-6-yl, etc.; R1 = Ph, Me, Bn, etc.; R2 = Ph, Me, Bn, n-pentyl, 4-cyanophenyl) with boronic acids R3B(OH)2 [R3 = 4-(methoxycarbonyl)phenyl, 4-methylnaphthalen-1-yl, 1-benzofuran-2-yl, etc.] to afford numerous diaryl sulfones RS(O)2R3 via a visible light-mediated N-S bond cleavage, rather than the typical transition-metal-catalyzed C(O)-N bond activation, is described. This methodol., which represents the first catalyst-free protocol for the sulfonylation of boronic acids, is characterized by its simple reaction conditions, good functional group tolerance and high efficiency. Several successful examples for the late-stage functionalization of diverse sulfonamides indicate the high potential utility of this method in pharmaceutical science and organic synthesis.
Chemical Science published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 5335-40-0 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO4S2, Synthetic Route of 5335-40-0.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics