Luzina, Elena L.; Popov, Anatoliy V. published the artcile< Synthesis of 1-aroyl(1-arylsulfonyl)-4-bis(trifluoromethyl)alkyl semicarbazides as potential physiologically active compounds>, Name: 4-(Difluoromethoxy)benzene-1-sulfonyl chloride, the main research area is preparation semicarbazide physiol active compound Lipinski Gelovani parameter.
1,1-Bis(trifluoromethyl)alkyl isocyanates obtained from perfluoroisobutene (PFIB) react with aroyl(arylsulfonyl)hydrazines. Twenty eight prospective biol. active polyfluorinated 1,4-substituted semicarbazides, e.g. I, were synthesized. The structure of each new product was confirmed by anal. and spectroscopic methods. The Lipinski’s and Gelovani’s parameters were then calculated Two adjustments to the Lipinski rules of five are suggested for fluorinated drug candidates.
Journal of Fluorine Chemistry published new progress about Semicarbazides Role: SPN (Synthetic Preparation), PREP (Preparation). 351003-34-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H5ClF2O3S, Name: 4-(Difluoromethoxy)benzene-1-sulfonyl chloride.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics