Miyagawa, Masayoshi; Akiyama, Toshiyuki; Mikamiyama-Iwata, Minako; Hattori, Kazunari; Kurihara, Naoko; Taoda, Yoshiyuki; Takahashi-Kageyama, Chika; Kurose, Noriyuki; Mikamiyama, Hidenori; Suzuki, Naoyuki; Takaya, Kenji; Tomita, Kenji; Matsuo, Kenji; Morimoto, Kenji; Yoshida, Ryu; Shishido, Takao; Yoshinaga, Tomokazu; Sato, Akihiko; Kawai, Makoto published the artcile< Discovery of novel 5-hydroxy-4-pyridone-3-carboxy acids as potent inhibitors of influenza Cap-dependent endonuclease>, HPLC of Formula: 16799-05-6, the main research area is hydroxy pyridonecarboxy acid preparation influenza Cap endonuclease inhibitor; Anti-influenza drug; Cap-dependent endonuclease; Chelator; Pyridone; Virtual modeling.
We report the discovery of a novel series of influenza Cap-dependent EndoNuclease (CEN) inhibitors based on the 4-pyridone-carboxylic acid (PYXA) scaffold, which were found from our chelate library. Our SAR research revealed the lipophilic domain to be the key to CEN inhibition. In particular, the position between the chelate and the lipophilic domain in the derivatives was essential for enhancing the potency. Our study, based on virtual modeling, led to the identification of 2y as a potent CEN inhibitor with an IC50 of 5.12 nM.
Bioorganic & Medicinal Chemistry Letters published new progress about Antiviral agents. 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, HPLC of Formula: 16799-05-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics