Pettinari, Riccardo; Marchetti, Fabio; Tombesi, Alessia; Di Nicola, Corrado; Pettinari, Claudio; Guo, Chuanpan; Zhang, Zhihong; Galindo, Agustin; Fadaei-Tirani, Farzaneh; Hadiji, Mouna; Dyson, Paul J. published the artcile< Arene-ruthenium(II) complexes with pyrazole-based ligands bearing a pyridine moiety: Synthesis, structure, DFT calculations, and cytotoxicity>, Recommanded Product: (Hexamethylbenzene)ruthenium(II) dichloride dimer, the main research area is arene ruthenium pyridinylpyrazolone pyridinyltrifluoroacetylpyrazolone preparation ruthenium complexation; crystal mol structure cytotoxicity arene ruthenium pyridinylpyrazolone pyridinyltrifluoroacetylpyrazolone complex.
Two pyrazole-based ligands bearing a pyridine moiety, 3-methyl-1-(pyridin-2-yl)-5-pyrazolone (HLpy), and 3-methyl-1-(pyridin-2-yl)-4-trifluoroacetyl-5-pyrazolone (HQpy,CF3), were prepared and fully characterized in the solid-state and the tautomerism of both ligands in solution was also rationalized by using D. Functional Theory. Neutral ruthenium(II) arene complexes of composition [Ru(arene)(Lpy)Cl] and [Ru(arene)(Qpy,CF3)Cl] [arene = p-cymene (cym) or hexamethylbenzene (hmb)] were synthesized and characterized by IR, 1H, 13C, 15N and 19F NMR spectroscopy, elemental anal. and ESI mass spectrometry. The structures of complexes [Ru(hmb)(Lpy)Cl] and [Ru(hmb)(Qpy,CF3)Cl] were determined by x-ray crystallog., showing κ2-N,N’-coordination not only for Lpy but also for Qpy,CF3 ligand. DFT studies confirm that κ2O,O’-coordination, generally observed in metal complexes with 4-acyl-5-pyrazolone ligands, is not favored in this case. The cytotoxicity of ligands and complexes was evaluated against human ovarian carcinoma cells (A2780 and A2780cisR, cisplatin sensitive and cisplatin-resistant, resp.), and non-tumorous human embryonic kidney SV40 transformed (HEK293T) cells to reveal essentially equivalent activity in the cisplatin sensitive and cisplatin-resistant ovarian carcinoma cells.
Inorganica Chimica Acta published new progress about Antitumor agents (kidney, and ovarian). 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Recommanded Product: (Hexamethylbenzene)ruthenium(II) dichloride dimer.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics