Porter, John; Lumb, Simon; Franklin, Richard J.; Gascon-Simorte, Jose M.; Calmiano, Mark; Le Riche, Kelly; Lallemand, Benedicte; Keyaerts, Jean; Edwards, Helen; Maloney, Alison; Delgado, Jean; King, Lloyd; Foley, Anne; Lecomte, Fabien; Reuberson, James; Meier, Christoph; Batchelor, Mark published the artcile< Discovery of 4-azaindoles as novel inhibitors of c-Met kinase>, Reference of 5335-40-0, the main research area is azaindole preparation cMet tyrosine kinase inhibitor.
A series of 4-azaindole inhibitors of c-Met kinase, e.g. I (R1 = H, NH2, CO2H, 1-piperazinyl, etc.; R2 = PhSO2, 2-O2NC6H4SO2, benzofurazan-4-ylsulfonyl, etc.), is described. The postulated binding mode was confirmed by an X-ray crystal structure of complex of I (R1 = CONH2; R2 = 2-O2NC6H4SO2) with c-Met kinase and series optimization was performed on the basis of this structure. Future directions for series development are discussed.
Bioorganic & Medicinal Chemistry Letters published new progress about Enzyme inhibitors. 5335-40-0 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO4S2, Reference of 5335-40-0.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics