Prabhakar, Virupakshi; Babu, Kondra Sudhakar; Ravindranath, L. K. published the artcile< Design and facile method for synthesis of novel 1,3,4-oxadiazole derivatives by using Biginelli reaction>, Quality Control of 672948-03-7, the main research area is oxadiazole preparation; tetrahydropyrimidine carbohydrazide carboxylic acid Biginelli reaction.
An efficient synthesis of 3,4-dihydropyrimidinones I from the thieno[2,3-d]pyrimidine-6-carboxaldehyde, Et 2-acetoacetate and urea in ethanol, using zirconium tetrachloride as the catalyst is described. A new series of 6-methyl-4-(thieno[2,3-d]pyrimidin-6-yl)-5-(5-p-substituted-1,3,4-oxadiazol-2-yl)-3,4-dihydropyrimidin-2(1H)-one derivatives II (R = C6H5, pyridin-4-yl, furan-2-yl, etc.) was synthesized after refluxing 6-methyl-2-oxo-4-(thieno[2,3-d]pyrimidin-6-yl)-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide with different aromatic/heterocyclic carboxylic acids RC(O)OH in the presence of POCl3.
Heterocyclic Letters published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 672948-03-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H3NO3, Quality Control of 672948-03-7.
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