Pyun, Sang Yong; Cho, Bong Rae published an article in Bulletin of the Korean Chemical Society. The title of the article was 《Reactions of 4-nitrophenyl 2-thiophenecarboxylates with R2NH/R2NH2+ in 20 mol % DMSO (aq). Effects of 5-thienyl substituent and base strength》.Recommanded Product: 1450877-56-1 The author mentioned the following in the article:
Reactions of 4-nitrophenyl 2-thiophenecarboxylate (1a-e) with R2NH/R2NH2+ in 20 mol % DMSO (aq) have been studied kinetically. The 2nd order kinetics, βnuc = 0.88-0.98, and linear Hammett and Yukawa-Tsuno plots observed for these reactions indicate an addition-elimination mechanism in which the 2nd step is rate limiting. The βnuc value increased with a stronger electron-withdrawing 5-thienyl substituent, the Hammett plots are linear except for X = MeO, and Yukawa-Tsuno plots are linear with ρ = 0.79-1.32 and r = 0.28-0.93, resp. The ρ value increased and r value decreased with a stronger nucleophile, indicating an increase in the electron d. at the C = O bond and a decrease in the resonance demand. These results have been interpreted with enhanced N-C bond formation in the transition state with the reactivity increase. The results came from multiple reactions, including the reaction of 4-Nitrophenyl 5-chlorothiophene-2-carboxylate(cas: 1450877-56-1Recommanded Product: 1450877-56-1)
4-Nitrophenyl 5-chlorothiophene-2-carboxylate(cas: 1450877-56-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 1450877-56-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics