Qu, Tengfei; Qu, Lailiang; Wang, Xiaoguang; Xu, Ting; Xiao, Xiao; Ding, Min; Deng, Li; Guo, Yong published the artcile< Design, synthesis, and antibacterial activity of novel 8-methoxyquinoline-2-carboxamide compounds containing 1,3,4-thiadiazole moiety>, Related Products of 70057-67-9, the main research area is arylthiadiazolyl methoxyquinoline carboxamide preparation antibacterial activity SAR; 1,3,4-thiadiazole; 2-methyl-8-hydroxyquinoline; antibacterial activity; structure-activity relationships.
A series of novel 8-methoxyquinoline-2-carboxamide compounds containing 1,3,4-thiadiazole moiety was designed and synthesized by using an active substructure combination method. Then, the antibacterial activities of all the target compounds were evaluated in-vitro against three Gram-pos. bacteria and three Gram-neg. bacteria. The antibacterial assay showed that some target compounds displayed moderate to good antibacterial efficacy in comparison with the reference drug chloromycin. Some interesting results of structure-activity relationships were also discussed.
Zeitschrift fuer Naturforschung, C: Journal of Biosciences published new progress about Antibacterial agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Related Products of 70057-67-9.
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