Rafique, Rafaila; Khan, Khalid Mohammed; Arshia; Chigurupati, Sridevi; Wadood, Abdul; Rehman, Ashfaq Ur; Salar, Uzma; Venugopal, Vijayan; Shamim, Shahbaz; Taha, Muhammad; Perveen, Shahnaz published the artcile< Synthesis, in-vitro α-amylase inhibitory, and radicals (DPPH & ABTS) scavenging potentials of new N-sulfonohydrazide substituted indazoles>, Application In Synthesis of 22952-32-5, the main research area is phenyl tetrahydroindazolone preparation; tetrahydroindazolylidene sulfonohydrazide diastereoselective preparation; amylase inhibition kinetics antioxidant activity SAR docking; ABTS and DPPH; In silico; In vitro; Indazole; Sulfonohydrazide; α-amylase enzyme.
A series of new N-sulfonohydrazide substituted indazoles I and II [R = Me, Ph, 1-naphthyl, etc.] were synthesized by multistep reaction scheme and assessed for in-vitro α-amylase inhibitory and radical (DPPH and ABTS) scavenging properties. All compounds I and II were fully characterized by different spectroscopic techniques including 1H, 13C NMR, EI-MS, HREI-MS, ESI-MS and HRESI-MS. Compounds I and II showed promising α-amylase inhibitory activities (IC50 = 1.23 ± 0.06-4.5 ± 0.03μM) as compared to the standard acarbose (IC50 1.20 ± 0.09μM). In addition to that all derivatives were found good to moderate scavengers of DPPH (IC50 = 2.01 ± 0.13-5.3 ± 0.11) and ABTS (IC50 = 2.34 ± 0.07-5.5 ± 0.07μM) radicals, in comparison with standard ascorbic acid having scavenging activities with IC50 = 1.99 ± 0.09μM and IC50 = 2.03 ± 0.11μM for DPPH and ABTS radicals. In-silico mol. docking study was conducted to rationalized the binding interaction of α-amylase enzyme with ligands. Compounds were observed as mixed type inhibitors in enzyme kinetic characterization.
Bioorganic Chemistry published new progress about Antioxidants. 22952-32-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O3S, Application In Synthesis of 22952-32-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics