Rani, Dixita; Bhargava, Meha; Agarwal, Jyoti published the artcile< Asymmetric Michael Addition of Unactivated Ketones with β-Nitrostyrenes Mediated by Bifunctional L-Prolinamide Organocatalysts>, Quality Control of 5153-70-8, the main research area is nitrostyrene ketone orgnocatalyst diastereoselective Michael addition; nitrophenylethyl ketone preparation.
The catalytic activity of two types of L-prolinamide organocatalysts was investigated for asym. Michael addition reaction of cyclic/acyclic ketones with β-nitrostyrens. L-Prolinamides bearing amino groups as efficient catalyst as well as selectivity was found to be dependent upon the position of amine group to the amide bond. Organocatalyst having -NH2 group ortho to amide bond provided the best results. Substrate scope was also studied by performing the reaction of various β-nitrostyrenes with ketones to afforded the corresponding Michael adducts in excellent yields with very high diastereoselectivities and enantioselectivities in almost all cases.
ChemistrySelect published new progress about Alkenes, nitro Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Quality Control of 5153-70-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics