Sitte, Nikolai A.; Bursch, Markus; Grimme, Stefan; Paradies, Jan published the artcile< Frustrated Lewis Pair Catalyzed Hydrogenation of Amides: Halides as Active Lewis Base in the Metal-Free Hydrogen Activation>, Electric Literature of 17082-09-6, the main research area is carboxylic amide hydrogen borane oxalyl chloride hydrogenation catalyst; amine tertiary preparation.
A method for the metal-free reduction of carboxylic amides using oxalyl chloride as an activating agent and hydrogen as the final reductant is introduced. The reaction proceeds via the hydrogen splitting by B(2,6-F2-C6H3)3 in combination with chloride as the Lewis base. D. functional theory calculations support the unprecedented role of halides as active Lewis base components in the frustrated Lewis pair mediated hydrogen activation. The reaction displays broad substrate scope for tertiary benzoic acid amides and α-branched carboxamides.
Journal of the American Chemical Society published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (carboxylic amides). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Electric Literature of 17082-09-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics