Skoczynska, Anna; Pasternak, Beata; Malecka, Magdalena; Krajewska, Urszula; Mirowski, Marek; Merecz-Sadowska, Anna; Karwowski, Boleslaw T.; Kusz, Joachim; Budzisz, Elzbieta published the artcile< The cytotoxic effect of Ru(II) complexes with 5-(2-hydroxyphenyl)-3-methyl-1-(2-pyridyl)-1H-pyrazole-4-carboxylic acid methyl ester: Synthesis, X-ray structure and DNA damage potential>, Safety of (Hexamethylbenzene)ruthenium(II) dichloride dimer, the main research area is hydroxyphenyl pyridylpyrazole carboxylate ruthenium arene complex preparation DNA damage; antitumor activity hydroxyphenyl pyridylpyrazole carboxylate ruthenium arene complex; crystal mol structure cymeneruthenium hydroxyphenyl pyridylpyrazole carboxylate complex.
A series of arene ruthenium(II) complexes, 1a-3a, with the general formula [(η6-arene)Ru(L)Cl2] (where arene = p-cymene, hexamethylbenzene and benzene, resp., and L = 5-(2-hydroxyphenyl)-3-methyl-1-(2-pyridyl)-1H-pyrazole-4-carboxylic acid Me ester) were synthesized and characterized by elemental anal., MS, IR and 1H NMR spectroscopy. The stability of selected complexes was assessed by UV-Vis spectroscopy over 24 and 48 h periods. The synthesized complexes were evaluated for in vitro experiments using HL-60, NALM-6, WM-115 and COLO-205, and they showed low cytotoxic activity. The most active compound, 2a, possesses IC50 = 41.17 ± 3.68 μM, which is comparable to the reference compound quercetin. X-ray crystallog. anal. of compound 1a found that the ruthenium complex adopts a piano-stool type of geometry, with crystal packing stabilized by a 3-D net of O-H…Cl and C-H…Cl type hydrogen bonds, the latter forming dimers in the crystal lattice. The most active complexes in the cytotoxicity experiments were selected for evaluation of the damage percentage in NALM-6 cells by a comet assay: the extent of DNA fragmentation in the lymphoblastic leukemia cells indicated that the analyzed ruthenium(II) complexes triggered DNA damage.
Polyhedron published new progress about Antitumor agents. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Safety of (Hexamethylbenzene)ruthenium(II) dichloride dimer.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics