Tan, Zhenda; Xiong, Biao; Yang, Jian; Ci, Chenggang; Jiang, Huanfeng; Zhang, Min published the artcile< Selective reductive cross-coupling of N-heteroarenes by an unsymmetrical PNP-ligated manganese catalyst>, HPLC of Formula: 320407-92-9, the main research area is tetrahydronaphthyridine preparation regioselective chemoselective; indole naphthyridine reductive cross coupling manganese catalyst; pyrrole naphthyridine reductive cross coupling manganese catalyst; heteroarene naphthyridine reductive cross coupling manganese catalyst.
Herein, by developing an unprecedented manganese catalyst ligating with an unsym. 2-aminotetrahydronaphthyridyl PNP-ligands e.g., I, a new reductive cross-coupling of indoles II (R = H, 5-MeO, 7-Me, 2,5-di-Me, etc.)/1H-pyrrole, 2,5-dimethyl-1H-pyrrole and N-heteroarenes III (R1 = H, 2,3-di-Me, 4-chlorophenyl, thiophen-2-yl, etc.; X = CH, N) was achieved. Mechanistic investigations show that the catalyst-enabled in situ capture of the partially reduced intermediates by interruption of the second transfer hydrogenation of N-heteroarenes constitutes the key to success for the present reaction. The developed chem. proceeds with good substrate and functional group compatibility, high step and atom efficiency, and excellent chemo and regioselectivity, and is applicable for late-stage modification of pyridine-containing biomedical mols., which has established a new platform allowing the linkage of aromatic systems into functional frameworks, and further development of unsym. PNP organometallic complexes and related catalytic transformations.
Journal of Catalysis published new progress about Aromatic nitrogen heterocycles Role: SPN (Synthetic Preparation), PREP (Preparation). 320407-92-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrClO, HPLC of Formula: 320407-92-9.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics