Computed Properties of C8H6Cl2O3On October 31, 2008 ,《Bioactive metabolites from Penicillium sp., an endophytic fungus residing in Hopea hainanensis》 appeared in World Journal of Microbiology & Biotechnology. The author of the article were Wang, F. W.; Hou, Z. M.; Wang, C. R.; Li, P.; Shi, D. H.. The article conveys some information:
The metabolites of endophytic fungus Penicillium sp. from the leaf of Hopea hainanensis were reported for the first time. By bioassay-guided fractionation, the EtOAc extract of a solid-matrix steady culture of this fungus afforded six compounds, which were identified through a combination of spectral and chem. methods (IR, MS, 1H- and 13C-NMR) to be monomethylsulochrin (1), rhizoctonic acid (2), asperfumoid (3), physcion (4), 7,8-dimethyl-iso-alloxazine (5) and 3,5-dichloro-p-anisic acid (6). Compounds 2, 3 and 6 were obtained from Penicillium sp. for the first time. All of the six isolates were subjected to in vitro bioactive assays including antifungal action against three human pathogenic fungi Candida albicans, Trichophyton rubrum and Aspergillus niger and cytotoxic activity against the human nasopharyngeal epidermoid tumor KB cell line and human liver cancer HepG2 cell line. As a result, compounds 2-4 and 6 inhibited the growth of C. albicans with MICs of 40.0, 20.0, 50.0 and 15.0 μg/mL, resp. and the compound 6 showed growth inhibition against A. niger with MICs of 40.0 μg/mL. In addition, compounds 1-3 and 6 exhibited cytotoxic activity against KB cell line with IC50 value of 30.0, 20.0, 20.0, 5.0 μg/mL, resp. and against HepG2 cell line with IC50 value of 30.0, 25.0, 15.0, 10.0 μg/mL, resp. The results came from multiple reactions, including the reaction of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Computed Properties of C8H6Cl2O3)
3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C8H6Cl2O3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics