Wang, Qian; Tao, Quan; Dong, Hui; Ni, Chuanfa; Xie, Xiaoming; Hu, Jinbo published the artcile< Fluorination Triggers Fluoroalkylation: Nucleophilic Perfluoro-tert-butylation with 1,1-Dibromo-2,2-bis(trifluoromethyl)ethylene (DBBF) and CsF>, Recommanded Product: 4-(Bromomethyl)-2-chloro-1-methoxybenzene, the main research area is electrophile fluorination fluoroalkylation dibromo bistrifluoromethylethylene magnetic resonance imaging safety; perfluoro tert butylated compound preparation; fluorination; fluoroalkylation; imaging probes; magnetic resonance imaging; perfluoro-tert-butylation.
Perfluoro-tert-butylation reaction has long remained a challenging task. We now report the use of 1,1-dibromo-2,2-bis(trifluoromethyl)ethylene (DBBF, I) as a practical reagent for perfluoro-tert-butylation reactions for the first time. Through a consecutive triple-fluorination process with DBBF and CsF, the (CF3)3C- species can be liberated and observed, which is able to serve as a robust nucleophilic perfluoro-tert-butylating agent for various electrophiles. The power of this synthetic protocol is evidenced by the efficient synthesis of structurally diverse perfluoro-tert-butylated mols. Multiple applications demonstrate the practicability of this method, as well as the superiority of perfluoro-tert-butylated compounds as sensitive probes. The perfluoro-tert-butylated product was successfully applied in 1H- and 19F-magnetic resonance imaging (MRI) experiment with an ultra-low field (ULF) MRI system.
Angewandte Chemie, International Edition published new progress about Electrophiles. 320407-92-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrClO, Recommanded Product: 4-(Bromomethyl)-2-chloro-1-methoxybenzene.
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics