《Iridium-catalyzed C-H amidation of s-tetrazines》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Xiong, Huan; Gu, Yuang; Zhang, Shuning; Lu, Fengping; Ji, Qun; Liu, Lili; Ma, Peixiang; Yang, Guang; Hou, Wei; Xu, Hongtao. Quality Control of Thiophene-2-sulfonyl chloride The article mentions the following:
An efficient, selective and scalable C-H amidation of s-tetrazines under iridium(III) catalysis was reported to affor amido-aryl tetrazines such as I [R1 = H, 3-Br, 4-CF3, etc.; R2 = NHSO2n-Bu, NHSO2Ph, NHTs, etc.; R3 = H, NHSO2Ph, NHTs, etc.]. This reaction featured a broad substrate scope, high functional group tolerance and air and water tolerance. This reaction also showed great potential for the rapid preparation of tri- and tetra-functional building blocks, which could be applied either in bioconjugation or synthesis of DNA-encoded library. In the experimental materials used by the author, we found Thiophene-2-sulfonyl chloride(cas: 16629-19-9Quality Control of Thiophene-2-sulfonyl chloride)
Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Quality Control of Thiophene-2-sulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics