《Palladium-catalyzed cross-coupling reaction of sulfoxonium ylides and benzyl bromides by carbene migratory insertion》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Yan, Kaichuan; He, Maoyao; Li, Jianglian; He, Hua; Lai, Ruizhi; Luo, Yi; Guo, Li; Wu, Yong. Reference of 1-(Bromomethyl)-4-chlorobenzene The article mentions the following:
A palladium-catalyzed cross-coupling reaction of sulfoxonium ylides 3-R-4-R1-C6H3C(C(O)OR2)=S(O)(CH3)2 [R = H, OMe; R1 = H, Cl, Me; R2 = Et, i-Bu] and benzyl bromides R3CH(R4)Br (R3 = ethenyl, Ph, naphthalen-2-yl, etc.; R4 = H, Ph) has been developed, which has potential safety advantages over previous carbene coupling reactions using either diazo compounds or their in situ precursors. This reaction affords polysubstituted olefins (Z/E)-3-R-4-R1-C6H3C(C(O)OR2)=C(R3)R4, and features good substrate tolerance and is suitable for late-stage modification of biol. active mols. Pd-carbene migratory insertion is supposed to be involved in this coupling reaction.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Reference of 1-(Bromomethyl)-4-chlorobenzene) was used in this study.
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Reference of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics