Zhang, Wei; Xiang, Xin-Xin; Chen, Junyi; Yang, Chen; Pan, Yu-Liang; Cheng, Jin-Pei; Meng, Qingbin; Li, Xin published the artcile< Direct C-H difluoromethylation of heterocycles via organic photoredox catalysis>, Reference of 2382-10-7, the main research area is difluoromethylation regioselective organic photoredox catalysis; heteroarene sodium difluoromethanesulfinate difluoromethylation aerobic.
The discovery of modern medicine relies on the sustainable development of synthetic methodologies to meet the needs associated with drug mol. design. Heterocycles containing difluoromethyl groups are an emerging but scarcely investigated class of organofluoro mols. with potential applications in pharmaceutical, agricultural and material science. Herein, authors developed an organophotocatalytic direct difluoromethylation of heterocycles using O2 as a green oxidant. The C-H oxidative difluoromethylation obviates the need for pre-functionalization of the substrates, metals and additives. The operationally straightforward method enriches the efficient synthesis of many difluoromethylated heterocycles in moderate to excellent yields. The direct difluoromethylation of pharmaceutical moleculars demonstrates the practicability of this methodol. to late-stage drug development. Moreover, 2′-deoxy-5-difluoromethyluridine exhibits promising activity against some cancer cell lines, indicating that the difluoromethylation methodol. might provide assistance for drug discovery.
Nature Communications published new progress about Antitumor agents. 2382-10-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H4Cl2N4, Reference of 2382-10-7.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics