Bhansali, Pravin; Hanigan, Christin L.; Casero, Robert A.; Tillekeratne, L. M. Viranga published the artcile< Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: Synthesis and biological evaluation>, Computed Properties of 19995-38-1, the main research area is peptidomimetic largazole enantioselective synthesis antitumor structure activity chelator zinc; cyclopeptide histone deacetylase inhibitor tubulin acetylation colon carcinoma; cyclocondensation enzymic resolution Wittig reaction aldol condensation; conjugate addition acyl transfer coupling Yamaguchi esterification macrolactamization trityl; chiral auxiliary acetyl Nagao transition state structure.
The histone deacetylase inhibitor largazole was synthesized by a convergent approach that involved several efficient and high yielding single pot multistep protocols. Initial attempts using tert-Bu as thiol protecting group proved problematic, and synthesis was accomplished by switching to the trityl protecting group. This synthetic protocol provides a convenient approach to many new largazole analogs. Three side chain analogs with multiple heteroatoms for chelation with Zn2+ were synthesized, and their biol. activities were evaluated. They were less potent than largazole in growth inhibition of HCT116 colon carcinoma cell line and in inducing increases in global H3 acetylation. Largazole and the three side chain analogs had no effect on HDAC6, as indicated by the lack of increased acetylation of α-tubulin.
Journal of Medicinal Chemistry published new progress about Acetylation. 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, Computed Properties of 19995-38-1.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics