Cao, Xiufang’s team published research in Chemical Biology & Drug Design in 2012-07-31 | 29027-20-1

Chemical Biology & Drug Design published new progress about Fungicides (antifungal). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Application In Synthesis of 29027-20-1.

Cao, Xiufang; Xu, Shengzhen; Li, Xuegang; Shen, Xiaoxia; Zhang, Qingye; Li, Jianhong; Chen, Changshui published the artcile< N-nitrourea derivatives as novel potential fungicides against Rhizoctonia solani: synthesis, antifungal activities, and 3D-QSAR>, Application In Synthesis of 29027-20-1, the main research area is antifungal nitrourea derivative.

N-nitrourea derivatives bearing various aryl substituents were obtained via three steps, including nitration, carbamic chlorination, and aminolysis reactions. The structures of all the newly synthesized compounds were characterized and confirmed by IR, 1H-NMR, MS, and elemental anal. Bioassays indicated that five of the compounds possess fungicidal activity against Rhizoctonia solani. Structure-activity relationship (SAR) is also discussed based on the exptl. data, and the further quant. structure-activity relationship (QSAR) was analyzed using comparative mol. field anal. and comparative mol. similarity indexes anal.

Chemical Biology & Drug Design published new progress about Fungicides (antifungal). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Application In Synthesis of 29027-20-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics