Gallagher, Rory T.; Basu, Souradeep; Stuart, David R. published the artcile< Trimethoxyphenyl (TMP) as a Useful Auxiliary for in situ Formation and Reaction of Aryl(TMP)iodonium Salts: Synthesis of Diaryl Ethers>, Synthetic Route of 16766-30-6, the main research area is diaryl ether preparation chemoselective; aryl iodonium salt arylation.
Herein, a synthetic approach for arylation that exploits the in situ formation and reaction of an unsym. diaryliodonium salt is described. In this way, aryl iodides are used as reagents in a metal-free reaction with phenols, and a trimethoxyphenyl (TMP) group is used as a “”dummy”” group to facilitate transfer of a wide range of aryl moieties. The scope of aryl electrophiles and phenol nucleophiles is broad (>30 examples) and the yields are high (52-95%, 80% avg.). One-pot coupling reactions avoid the synthesis of diaryliodonium salts and provide opportunities for sequential reactions and novel chemoselectivity.
Advanced Synthesis & Catalysis published new progress about Aromatic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, Synthetic Route of 16766-30-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics