Genc, Hayriye Nevin; Ozgun, Ummu; Sirit, Abdulkadir published the artcile< Design, synthesis and application of chiral tetraoxacalix[2]arene[2]triazine-based organocatalysts in asymmetric Michael addition reactions>, Application In Synthesis of 5153-70-8, the main research area is aryl dimethyl nitrobutanal preparation enantioselective; isobutyraldehyde nitrostyrene Michael oxacalixarene triazine organocatalyst; Michael addition; asymmetric synthesis; organocatalysis; stereoselectivity; tetraoxacalix[2]arene[2]triazine.
A novel type of (R,S)/(S,R)-oxacalix[2]arene[2]triazine-based organocatalysts I for asym. Michael reactions is reported for the first time. Chiral subunits were attached to the heteroatom-bridged calixarom. platform by a reaction of (R)- and (S)-1-aminotetraline with tetraoxacalix[2]arene[2]triazine in both enantiomeric forms. To evaluate the catalytic efficiency of the novel organocatalysts , isobutyraldehyde reacted with various substituted and unsubstituted aromatic trans-β-nitrostyrenes (E)-RCH=CHNO2 (R = Ph, 2-bromophenyl, furan-2-yl, etc.) in THF (THF), leading to Michael adducts (S)-HC(O)C(CH3)2CH(R)CH2NO2 in excellent yields and enantioselectivites (up to 97% yield and 99% ee).
Chirality published new progress about Aromatic hydrocarbons Role: SPN (Synthetic Preparation), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Application In Synthesis of 5153-70-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics