Han, Yong; Zheng, Bo; Peng, Yungui published the artcile< Construction of Chiral 2-Substituted Octahydroindoles from Cyclic Ketones and Nitroolefins Bearing only One α-Substituent>, COA of Formula: C8H8BrCl, the main research area is cyclic ketone nitroolefin amine phosphoric acid catalyst Michael addition; gamma nitro ketone preparation enantioselective intramol reductive amination; octahydroindole preparation.
A dual catalytic system was developed following the screening of a series of chiral primary amine catalysts and chiral phosphoric acid catalysts for the Michael addition of cyclic ketones to nitroolefins bearing only one α-substituent. The resulting γ-nitro ketones, which contain a substituent on the carbon connected to the nitro group, were formed in excellent yields (>80%) with high levels of stereoselectivity (up to 94:6 dr and 98% ee) when the reaction was performed in benzene at 0° with 10 mol% of the optimal amine/phosphoric acid combination (1:1) as a catalyst. Subsequent reduction of the nitro group followed by intramol. reductive amination afforded optically active cis-octahydroindole analogs bearing a non-functional substituent at their 2-position.
Advanced Synthesis & Catalysis published new progress about Alkenes, nitro Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, COA of Formula: C8H8BrCl.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics