Hanessian, Stephen; Therrien, Eric; van Otterlo, Willem A. L.; Bayrakdarian, Malken; Nilsson, Ingemar; Fjellstroem, Ola; Xue, Yafeng published the artcile< Phenolic P2/P3 core motif as thrombin inhibitors - design, synthesis, and X-ray co-crystal structure>, Formula: C7H6Cl2O2S, the main research area is trisubstituted phenol preparation thrombin inhibitor.
Prototypical thrombin inhibitors were synthesized based on a trisubstituted phenol as a core motif. A naphthylsulfonamide analog (I) showed excellent antithrombin activity. An X-ray co-crystal structure of I bound to thrombin showed the expected interactions.
Bioorganic & Medicinal Chemistry Letters published new progress about Phenols Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), BIOL (Biological Study), PREP (Preparation). 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Formula: C7H6Cl2O2S.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics