Ivachtchenko, Alexandre V.; Golovina, Elena S.; Kadieva, Madina G.; Koryakova, Angela G.; Kovalenko, Sergiy M.; Mitkin, Oleg D.; Okun, Ilya M.; Ravnyeyko, Irina M.; Tkachenko, Sergey E.; Zaremba, Oleg V. published the artcile< Synthesis and biological study of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines as potent and selective serotonin 5-HT6 receptor antagonists>, Recommanded Product: 3-Chloro-5-methylaniline, the main research area is serotonin 5HT6 antagonist triazolopyrimidine preparation structure activity combinatorial library.
A number of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines were prepared and their 5-HT6 receptor binding affinity and ability to inhibit the functional cellular responses to serotonin were evaluated. 3-[(3-Chlorophenyl)sulfonyl]-N-(tetrahydrofuran-2-ylmethyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine 2{5,26} appeared to be the most active in a functional assay (IC50 = 29.0 nM) and 3-(phenylsulfonyl)-N-(2-thienylmethyl) thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine 2{1,28} demonstrated the greatest affinity in a 5-HT6 receptor radioligand binding assay (K i = 1.7 nM). A screening of 5-HT2A and 5-HT2B receptor affinity revealed that 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines are highly selective 5-HT6 receptor ligands.
Bioorganic & Medicinal Chemistry published new progress about 5-HT1A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (antagonists). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Recommanded Product: 3-Chloro-5-methylaniline.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics