Kaur, Sukhvir; Kaur, Manjinder; Kaur, Jasmeen; Bansal, Yogita; Bansal, Gulshan published the artcile< Synthesis, antimicrobial evaluation and chemical stability studies of novel trisubstitued benzimidazoles>, Safety of 1-Chloro-2-(chloromethyl)benzene, the main research area is benzoyl nitrobenzimidazole preparation antibacterial antifungal docking SAR enzyme inhibitor; benzyl nitrobenzimidazole preparation antibacterial antifungal docking SAR enzyme inhibitor.
The current study was aimed at designing, synthesizing and exploring novel benzimidazoles derived compounds I [R = H, 2-Cl, 4-Cl, 4-O2N; R1 = 3-pyridinyl, 2-furyl; X = CH2, C=O] as potential antimicrobial agents. The designed compounds were synthesized from o-phenylenediamine, nicotinic acid, furfuraldehyde and varied benzoyl/benzyl chlorides through a 4-steps synthetic scheme. In-vitro antimicrobial evaluation was carried out by measuring zone of inhibition at different concentrations (1.56-100 μg/mL) of target compounds and streptomycin. Docking anal. was carried out using GlcN-6-P synthase as target enzyme as it was essential for microbial cell wall synthesis and docking studies showed good binding affinity of target compounds toward GlcN-6-P. Hydrolytic stability of the most active compound I [R = 4-Cl; R1 = 3-pyridinyl; X = C=O] in GIT was evaluated in non-enzymic simulated gastric and intestinal fluids through HPLC method. Compounds I [R = H, 2-Cl; R1 = 3-pyridinyl; X = CH2, C=O] exhibited good antibacterial activity, whereas I [R = H, 2-Cl, 4-O2N; R1 = 2-furyl; X = C=O] had potent antifungal properties. Compound I [R = 4-Cl; R1 = 3-pyridinyl; X = C=O] was maximally lethal from the series and equipotent to streptomycin against S. aureus, E. coli and P. aeruginosa with MIC 4.16 ± 1.04, 5.20 ± 1.04 and 10.41 ± 2.08 μg/mL, resp., compound I[R = 2-Cl; R1 = 2-furyl; X= C=O] (MIC 20.83 ± 4.16 μg/mL) was equipotent to fluconazole against C. albicans. Compound I [R = 4-Cl; R1 = 3-pyridinyl; X = C=O] was found stable in non-enzymic simulated gastric and intestinal fluids up to 4h.
Chemica Sinica published new progress about Amides, tertiary Role: PAC (Pharmacological Activity), PRP (Properties), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Safety of 1-Chloro-2-(chloromethyl)benzene.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics