Luecking, U. published the artcile< Neglected sulfur(VI) pharmacophores in drug discovery: exploration of novel chemical space by the interplay of drug design and method development>, Name: 1-Chloropyrrolidine-2,5-dione, the main research area is sulfur pharmacophore drug discovery design.
Historically, sulfoximines, sulfondiimines and sulfonimidamides have been neglected pharmacophores in drug discovery even though they offer very interesting properties. This highlight shares the key learnings of various lead optimization approaches at Bayer AG that have successfully utilized these neglected sulfur(VI) functional groups to deliver multiple clin. candidates. In this context, the key synthetic methods utilized for the synthetic preparation of these unusual compounds will be outlined.
Organic Chemistry Frontiers published new progress about Antiproliferative agents. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Name: 1-Chloropyrrolidine-2,5-dione.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics