Matsuno, Kenji; Takai, Kazushige; Isaka, Yoshinobu; Unno, Yuka; Sato, Masayuki; Takikawa, Osamu; Asai, Akira published the artcile< S-Benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase>, Category: chlorides-buliding-blocks, the main research area is benzylisothiourea derivative preparation indoleamine dioxygenase inhibitor.
S-Benzylisothiourea was discovered by its ability to inhibit indoleamine-2,3-dioxygenase (IDO) in our screening program. Subsequent optimization of the initial hit leads to the identification of sub-μM inhibitors of which suppressed kynurenine production in A431 cells. Synthesis and structure-activity relationship of S-benzylisothiourea analogs as small-mol. inhibitors of IDO are described.
Bioorganic & Medicinal Chemistry Letters published new progress about Enzyme inhibitors (indoleamine dioxygenase). 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Category: chlorides-buliding-blocks.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics