Rilvin-Derrick, Eloise; Oram, Niall; Richardson, Jeffery published the artcile< An Efficient Palladium-Catalyzed Aminocarbonylation of Benzyl Chlorides>, Related Products of 611-19-8, the main research area is chloromethyl arene amine carbon monoxide palladium catalyst aminocarbonylation; arylacetamide preparation.
An improved procedure for the aminocarbonylation of benzyl chloride derivatives using carbon monoxide and either primary or secondary amines were developed. Studying the competing background alkylation reaction allowed the solvent and base to be selected for a simple catalyst screen, which in turn, enabled the discovery of a method for the preparation of 2-arylacetamides under mild conditions, with minimal side-products using an inexpensive phosphine ligand. This non-traditional optimization strategy allowed us to overcome the background alkylation, which was cited as justification for the development of more complex and less atom-economical approaches.
Synlett published new progress about Acetamides Role: SPN (Synthetic Preparation), PREP (Preparation). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Related Products of 611-19-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics