Skidmore, John; Heer, Jag; Johnson, Christopher N.; Norton, David; Redshaw, Sally; Sweeting, Jennifer; Hurst, David; Cridland, Andrew; Vesey, David; Wall, Ian; Ahmed, Mahmood; Rivers, Dean; Myatt, James; Giblin, Gerard; Philpott, Karen; Kumar, Umesh; Stevens, Alexander; Bit, Rino A.; Haynes, Andrea; Taylor, Simon; Watson, Robert; Witherington, Jason; Demont, Emmanuel; Heightman, Tom D. published the artcile< Optimization of Sphingosine-1-phosphate-1 Receptor Agonists: Effects of Acidic, Basic, and Zwitterionic Chemotypes on Pharmacokinetic and Pharmacodynamic Profiles>, Name: Methyl 3-chloro-4-hydroxybenzoate, the main research area is sphingosine phosphate receptor agonist preparation pharmacokinetics.
The efficacy of the recently approved drug fingolimod (FTY720) in multiple sclerosis patients results from the action of its phosphate metabolite on sphingosine-1-phosphate S1P1 receptors, while a variety of side effects have been ascribed to its S1P3 receptor activity. Although S1P and phospho-fingolimod share the same structural elements of a zwitterionic headgroup and lipophilic tail, a variety of chemotypes have been found to show S1P1 receptor agonism. Here the authors describe a study of the tolerance of the S1P1 and S1P3 receptors toward bicyclic heterocycles of systematically varied shape and connectivity incorporating acidic, basic, or zwitterionic headgroups. The authors compare their physicochem. properties, their performance in in vitro and in vivo pharmacokinetic models, and their efficacy in peripheral lymphocyte lowering. The campaign resulted in the identification of several potent S1P1 receptor agonists, e.g. I, with good selectivity vs. S1P3 receptors, efficacy at <1 mg/kg oral doses, and developability properties suitable for progression into preclin. development. Journal of Medicinal Chemistry published new progress about Homo sapiens. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Name: Methyl 3-chloro-4-hydroxybenzoate.
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics