Sonawane, Rahul B.; Sonawane, Swapnali R.; Rasal, Nishant K.; Jagtap, Sangeeta V. published the artcile< Room-Temperature, Base-Mediated Selective Synthesis of 2-(Arylamino)ethanols and 2-Aryloxyethanols>, Reference of 611-19-8, the main research area is aniline chloroethanol potassium dichromate alkylation; phenyllamino ethanol bishydroxyethyl aniline preparation; phenol chloroethanol potassium dichromate alkylation; phenoxyethanol preparation.
A simple and efficient protocol for base-mediated selective synthesis of 2-(arylamino)ethanols from primary aromatic amines and 2-aryloxyethanols from phenols, promoted by K2CO3 was achieved under mild conditions. Even in presence of excess alkyl halide, selective mono-N-alkylation was achieved. Tolerance of a variety of functional groups was demonstrated by 15 examples of selective N-alkylation of aromatic amines and 19 examples of O-alkylation of phenols. The efficacy of the protocol was demonstrated by the formal synthesis of Ticlopidine, Vildagliptin, Quetiapine and Gemfibrozil .
SynOpen published new progress about Alkylation. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Reference of 611-19-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics