Tang, Sheng; Li, Yu-Huan; Cheng, Xin-Yue; Li, Ying-Hong; Wang, Hui-Qiang; Kong, Lan-Ying; Zhang, Xin; Jiang, Jian-Dong; Song, Dan-Qing published the artcile< SAR evolution and discovery of benzenesulfonyl matrinanes as a novel class of potential coxsakievirus inhibitors>, Formula: C7H7ClO4S2, the main research area is benzenesulfonyl matrinane coxsakievirus inhibitor structure activity relationship; coxsackieviruse; druggability; matrinane; matrinic acid; structure–activity relationship.
Materials & methods: Fifty-one novel 12N-substituted matrinic acid derivatives were synthesized and evaluated for their anti-coxsackievirus B3 activities. Results: Structure-activity relationship studies revealed that the 11-side chain could be determinant for the selectivity index by adjusting overall lipophilicity, and 11-butane was the best one for both potency and druggability. The optimized 35d showed the broad-spectrum anti-coxsackieviruse effects, an excellent pharmacokinetics and a good safety profile. More importantly, it displayed a potential effect for the pleconaril-resistant coxsackievirus B3 as well. Its mode of action is targeting on the viral transcription and translation stage, a different mechanism from that of pleconaril. Conclusion: Thus, we considered that 35d is a promising anti-enteroviral candidate for the treatment of various diseases infected with coxsackieviruses.
Future Medicinal Chemistry published new progress about Antiviral agents. 5335-40-0 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO4S2, Formula: C7H7ClO4S2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics