Thur, Yithachu; Bhalerao, Amit; Munshi, Zaki; Pansare, Nisha; Mann, Klaus; Hanauer, Guido; Kley, Hans-Peter; Nappe, Sandra; Weiss-Haljiti, Cornelia; Ostermann, Claude; Zitt, Christof; Schaefer, Michaela; Mondal, Dibyendu; Ali Siddiki, Afsar; Armugam, Velavan; Gudaghe, Vinod; Gupta, Mahendra; Rayudu, Pramila; Dautzenberg, Frank M.; Das Sarma, Koushik published the artcile< Structure-activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action>, Category: chlorides-buliding-blocks, the main research area is thienopyrancarboxamide preparation cannabinoid receptor analgesic SAR.
SAR studies were performed on a series of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists. Starting from a HTS hit both potency and selectivity could be improved. Modifications to the thiophene fusion and C-3 amides were studied. A representative compound 3t (I) produced analgesia when dosed orally in inflammatory pain models of writhing and carrageenan-induced allodynia.
Bioorganic & Medicinal Chemistry Letters published new progress about Allodynia. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Category: chlorides-buliding-blocks.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics